The movie follows two brilliant genetic engineers, Clive Nicoli (played by Adrien Brody) and Elsa Kast (played by Sarah Polley), who work for a pharmaceutical company. They are on the verge of a breakthrough in their research to create new hybrid organisms by splicing together different animal DNA.
Elsa persuades Clive to go beyond their company’s directives and secretly splice human DNA into their experiments. Despite Clive’s initial reluctance, they proceed and create a hybrid creature they name Dren (played by Delphine Chanéac). Dren rapidly grows from a small, amphibious creature into a humanoid being with both human and animal characteristics.
As Dren grows, she develops a complex and increasingly dangerous personality. She forms a close bond with Elsa but becomes hostile toward Clive, who fears the consequences of their actions. The relationship between the scientists and Dren becomes increasingly tense as they struggle to control her behavior and keep her existence a secret.
As Dren continues to evolve, she exhibits abilities and behaviors that challenge the scientists’ understanding of genetics and ethics. She becomes increasingly aggressive and unpredictable, posing a threat to everyone around her. Clive and Elsa must confront the consequences of their actions and decide what to do about Dren before it’s too late.
In the climax of the film, Dren’s true nature is revealed, and she goes on a rampage, attacking and killing several people. Clive and Elsa are forced to confront Dren in a final showdown, where they must decide whether to destroy her or try to save her. In a shocking twist, Dren’s true origins are revealed, and the consequences of the scientists’ actions come to light.
“Splice” is a thought-provoking and disturbing film that explores the ethical dilemmas surrounding genetic engineering and the boundaries of scientific progress. It raises questions about the consequences of playing with nature and the potential dangers of creating life in the laboratory. The film’s shocking twists and turns keep audiences on the edge of their seats until the very end.