The film is set in a world where cats and dogs engage in a secret, age-old battle for control of humanity. The story follows a group of animal agents, both canine and feline, who are part of a secret organization known as D.O.G. (Dog Intelligence Agency) and M.E.O.W.S. (Mousers Enforcing Our World’s Safety), respectively.
The central conflict arises when a rogue former M.E.O.W.S. agent named Kitty Galore (voiced by Bette Midler) plots to take over the world. Kitty, who has become disfigured and bitter, seeks revenge on both dogs and humans after a grooming accident leaves her without fur. She plans to broadcast a signal that will make all dogs go insane, rendering them helpless and paving the way for feline domination.
To stop Kitty’s nefarious plan, the D.O.G. agents recruit an inexperienced rookie named Diggs (voiced by James Marsden), a police dog who has been disgraced after a botched mission. Diggs is partnered with a seasoned D.O.G. agent named Butch (voiced by Nick Nolte), a tough and no-nonsense Anatolian Shepherd.
Meanwhile, a group of cats, led by a Russian Blue named Ivana (voiced by Christina Applegate), also joins the fight against Kitty Galore. Together, the dogs and cats must put aside their differences and work together to thwart Kitty’s evil scheme and save the world.
As the agents race against time to stop Kitty, they encounter various obstacles and challenges, including high-speed chases, daring rescues, and narrow escapes. Along the way, Diggs learns valuable lessons about teamwork, loyalty, and courage, ultimately proving himself to be a hero.
In the climactic showdown, the agents confront Kitty Galore at her secret lair, where a fierce battle ensues. With the help of their human allies, including a tech-savvy teenager named Catherine (played by Kiernan Shipka), the agents ultimately defeat Kitty and deactivate her doomsday device, saving the world from disaster.
In the end, Diggs is hailed as a hero, and the dogs and cats put aside their differences and embrace a newfound spirit of cooperation and friendship. “Cats & Dogs: The Revenge of Kitty Galore” ends on a lighthearted note, with the animals returning to their respective homes and living in harmony once again.