Adam Lerner (Joseph Gordon-Levitt) is a 27-year-old radio journalist living in Seattle. He is diagnosed with a rare form of cancer, a malignant tumor in his spine. Despite his young age, Adam faces the challenges of cancer treatment, including chemotherapy sessions and the uncertainty of his prognosis.
Adam’s best friend, Kyle (Seth Rogen), provides comedic relief and support throughout his treatment. Adam also attends therapy sessions with Katherine McKay (Anna Kendrick), a young and inexperienced therapist. As Adam navigates the physical and emotional toll of cancer, he begins to reevaluate his life and relationships.
The film portrays Adam’s interactions with his overbearing mother (Anjelica Huston), his strained relationship with his girlfriend (Bryce Dallas Howard), and the genuine friendships that emerge during his battle with cancer.
The climax of the film occurs as Adam faces a risky surgery to remove the tumor. The surgery’s outcome is uncertain, and Adam grapples with the possibility of his own mortality. The film explores themes of friendship, love, and the resilience of the human spirit.
The movie concludes with Adam navigating life after cancer treatment, with a new perspective and appreciation for the relationships that supported him. “50/50” is celebrated for its balance of humor and heartfelt moments, addressing the challenges of a serious medical condition with sensitivity and authenticity. The performances, particularly Joseph Gordon-Levitt’s portrayal of Adam, received praise for their emotional depth and authenticity.