After escaping rooms including electrocution, quicksand and acid rain, Zoey (Taylor Russell) is left as the only survivor. But, she then meets Amanda, who she thought died in the first Escape Room film and we learn survived and was recruited by Minos to design new games, like the one Ben and Zoey had been trying to escape.
Amanda tells her to not believe anyone is dead until she sees it with her own eyes, and learns than Ben didn’t die in the quicksand but was taken to use as leverage to force Zoey to design games, too. But, all three manage to escape and run to police station where they also learn on the news that their fellow players are dead.
The detective at the station tells Amanda they will hunt down the people behind Minos and Amanda and Ben head on a plane back home, where they are dealt a cruel twist of fate. Zoey thinks their way out of the game was too easy, and soon realises that her therapist had persuaded her to get on the plane by convincing her that Minos would be held accountable for the games. So, the police officer lied to them and they didn’t escape the game, they’re still playing.
The film ends with oxygen masks dropping from the aeroplane ceiling and the voice of a puzzle master telling Zoey that the games aren’t over until they say so.